Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription elements that play a essential position in neuroendocrine (NE) and neuroepithelial cell improvement. INSM1 has been recognized in a number of tumors of NE or neuroepithelial origin, whereas OTP expression has been primarily studied in NE tumors of pulmonary origin. Expression of OTP seems to correlate with poorer prognosis in pulmonary carcinoids; nevertheless, its expression patterns in different NE/neuroepithelial tumors want additional investigation.
Here, we assessed the diagnostic utility of INSM1 and OTP in tumors with NE differentiation at comparatively unusual websites together with prostate, breast, and tumors of gynecologic origin. Thirty-two formalin-fixed, paraffin-embedded circumstances have been used to assemble a tissue microarray. Immunohistochemistry for INSM1 and OTP was carried out and scored semi-quantitatively. INSM1 was diffusely expressed in 60% of gynecologic tumors, 71.4% of mammary carcinoma, and 25% of prostate adenocarcinoma with NE differentiation. Diffuse expression of OTP was detected in 50% of prostate adenocarcinoma with NE differentiation and 100% neuroendocrine carcinoma of the ovary.
Immunostain for achaete-scute homolog 1, chromogranin, synaptophysin, and CD56 supported the NE and/or neuroepithelial differentiation of the tumors. In abstract, INSM1 is expressed in most of the tumors with NE and neuroepithelial differentiation in this research, confirming the diagnostic utility of INSM1 as a novel and delicate marker of NE/neuroepithelial differentiation. The expression of OTP in some NE tumors outdoors of lung expands the spectrum of tumors that will specific this biomarker and ought to be thought of when working up a NE tumor of unknown major website.
Clinical and Pathologic Characteristics of Pulmonary Carcinoid Tumors in Central and Peripheral Locations.
Pulmonary carcinoid tumors happen in each central and peripheral areas, and some variations in clinico-pathological options have lengthy been noticed. We investigated a big quantity of resected carcinoid tumors with the intention to additional outline the traits of tumors from each areas. One hundred sixty-six resected carcinoid tumors of the lung have been analyzed for a range of medical and pathologic options, together with histology subtype, mitotic charge, Ki67 index, necrosis, invasive sample, architectural sample, cell morphology, sustentacular cells, neuroendocrine hyperplasia, and orthopedia homeobox protein (OTP) and TTF-1 immunohistochemical expressions.
Unsupervised hierarchical cluster evaluation recommended three clusters as the perfect resolution utilizing TTF-1 and OTP expression: TTF-1-positive and OTP-positive tumors as cluster 1, TTF-1-positive however OTP-negative as cluster 2, and TTF-1-negative and OTP-negative as cluster 3. Cluster 1 was characterised by peripheral location, presence of spindle cell element, presence of sustentacular cells, feminine predominance, and robust affiliation with neuroendocrine hyperplasia. Cluster 2 was characterised by central location, polygonal cell morphology, acinar progress sample in a subset of tumors, and solely uncommon affiliation with neuroendocrine hyperplasia.
Cluster Three consisted of extra aggressive tumors with extra heterogeneous pathologic options. Tumors confirmed polygonal cell morphology and acinar progress sample. Occurrence of neuroendocrine hyperplasia was distinctive. Our research confirmed distinct traits of central and peripheral sort carcinoid. An essential distinction was a robust affiliation of the peripheral tumor with neuroendocrine hyperplasia whereas such an affiliation in central tumors was negligible. The tumor location is likely to be related for pathobiology of lung carcinoid tumors.
The vitamin D historical past began early in the evolution of life (billion years in the past) as a photochemical response producing an inert molecule. During the early evolution of vertebrates, this molecule turned important for calcium and bone homeostasis of terrestrial animals and arrived to the standing of hormone. Phytoplankton, zooplankton, and most crops and animals which can be uncovered to daylight have the capability to make vitamin D. Vitamin D is critically essential for the event, progress, and upkeep of a wholesome skeleton from delivery till demise.
The main operate of vitamin D is to take care of calcium homeostasis. It accomplishes this by growing the effectivity of the gut to soak up dietary calcium. When there’s insufficient calcium in the food plan to fulfill the physique’s calcium requirement, vitamin D communicates to the osteoblasts that sign osteoclast precursors to mature and dissolve the calcium saved in the bone. The typical “vitamin D-deficiency” dysfunction was noticed for rising youngsters in the west and south of England in the early 1600s. This illness was described by Glisson and named “rickets” (recognized additionally as “the English illness”) and was noticed with epidemic proportions in northern Europe and North America. The corrections of deformities of rickets have been at the origin of the title “orthopedia” and of the approach of osteotomies.
Vitamin D: half I; from plankton and calcified skeletons (500 million years in the past) to rickets.
The vitamin D historical past began early in the evolution of life (billion years in the past) as a photochemical response producing an inert molecule. During the early evolution of vertebrates, this molecule turned important for calcium and bone homeostasis of terrestrial animals and arrived to the standing of hormone. Phytoplankton, zooplankton, and most crops and animals which can be uncovered to daylight have the capability to make vitamin D. Vitamin D is critically essential for the event, progress, and upkeep of a wholesome skeleton from delivery till demise.
![]() Alpha-bungarotoxin, CF680r |
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9-00003 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin, CF640r |
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9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-bungarotoxin, CF640r |
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9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin, CF488a |
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9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-bungarotoxin CF488a |
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9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin, CF568 |
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9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-bungarotoxin, CF568 |
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9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin, CF594 |
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9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-bungarotoxin CF594 |
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9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin, CF633 |
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9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-bungarotoxin, CF633 |
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9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin |
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00010-1 | Biotium | 1MG | EUR 168 |
Description: Minimum order quantity: 1 unit of 1MG |
![]() Fluorescein-Alpha-bungarotoxin |
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00011 | Biotium | 500uG | EUR 367 |
Description: Minimum order quantity: 1 unit of 500uG |
![]() Tetramethylrhodamine-Alpha-bungarotoxin |
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00012 | Biotium | 500uG | EUR 383 |
Description: Minimum order quantity: 1 unit of 500uG |
![]() Fluorescein-alpha-bungarotoxin: (10x50ug) |
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00013 | Biotium | 10ST | EUR 417 |
Description: Minimum order quantity: 1 unit of 10ST |
![]() Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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00014 | Biotium | 10ST | EUR 466 |
Description: Minimum order quantity: 1 unit of 10ST |
![]() Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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00015 | Biotium | 500uG | EUR 466 |
Description: Minimum order quantity: 1 unit of 500uG |
![]() Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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00016 | Biotium | 10ST | EUR 523 |
Description: Minimum order quantity: 1 unit of 10ST |
![]() Biotin-xx-a-bungarotoxin |
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00017 | Biotium | 500uG | EUR 433 |
Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-Bungarotoxin, CF555 conjugate |
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9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
![]() Alpha-Bungarotoxin, CF555 conjugate |
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9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
![]() Biotin-cAMP, diisopropylethylammonium salt: |
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00020 | Biotium | 1MG | EUR 314 |
Description: Minimum order quantity: 1 unit of 1MG |
![]() Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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00020-1 | Biotium | 20ST | EUR 418 |
Description: Minimum order quantity: 1 unit of 20ST |
![]() Biotin-cGMP, diisopropylethylammonium salt: |
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00021 | Biotium | 1MG | EUR 344 |
Description: Minimum order quantity: 1 unit of 1MG |
![]() Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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00021-1 | Biotium | 20ST | EUR 448 |
Description: Minimum order quantity: 1 unit of 20ST |
![]() Cyanine 644-cAMP: |
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00022 | Biotium | 1MG | EUR 491 |
Description: Minimum order quantity: 1 unit of 1MG |
![]() Cyanine 644-cAMP: (20x50ug) |
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00022-1 | Biotium | 20ST | EUR 625 |
Description: Minimum order quantity: 1 unit of 20ST |
![]() Fluorescein Methotrexate, triammonium salt: |
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00023 | Biotium | 1MG | EUR 281 |
Description: Minimum order quantity: 1 unit of 1MG |
![]() Staurosporine |
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00025 | Biotium | 100uG | EUR 139 |
Description: Minimum order quantity: 1 unit of 100uG |
![]() Alpha-bungarotoxin, CF543 |
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00026 | Biotium | 500uG | EUR 494 |
Description: Minimum order quantity: 1 unit of 500uG |
![]() Rhodamine phalloidin 300u |
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00027 | Biotium | 300 | EUR 345 |
Description: Minimum order quantity: 1 unit of 300 |
![]() Biotin-xx-phalloidin |
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00028 | Biotium | 100U | EUR 428 |
Description: Minimum order quantity: 1 unit of 100U |
![]() Fluorescein-phalloidin |
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00030 | Biotium | 300U | EUR 345 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Rhodamine 110 phalloidin |
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00032 | Biotium | 300ST | EUR 345 |
Description: Minimum order quantity: 1 unit of 300ST |
![]() Sulforhodamine 101 (Texas-Red) Phalloidin |
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00033 | Biotium | 300EU | EUR 345 |
Description: Minimum order quantity: 1 unit of 300EU |
![]() Phalloidin, CF405M |
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00034 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF405M |
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00034-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() CF488A-cAMP |
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00036 | Biotium | 100ug | EUR 172 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() CF640R-cAMP |
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00037 | Biotium | 100ug | EUR 172 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Phalloidin, CF555 |
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00040 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF555 |
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00040-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF647 |
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00041 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF647 |
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00041-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF488A |
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00042 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF488A |
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00042-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF543 |
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00043 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF543 |
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00043-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF568 |
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00044 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF568 |
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00044-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF594 |
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00045 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF594 |
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00045-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF633 |
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00046 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF633 |
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00046-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF660R |
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00047 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF660R |
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00047-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF680R |
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00048 | Biotium | 300U | EUR 466 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF680R |
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00048-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF350 |
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00049 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF350 |
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00049-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF640R |
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00050 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF640R |
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00050-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF532 |
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00051 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF532 |
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00051-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF660C |
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00052 | Biotium | 300U | EUR 442 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF660C |
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00052-T | Biotium | 50U | EUR 133 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF680 |
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00053 | Biotium | 300U | EUR 466 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF680 |
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00053-T | Biotium | 50U | EUR 147 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF430 |
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00054 | Biotium | 300U | EUR 449 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF430 |
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00054-T | Biotium | 50U | EUR 139 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Phalloidin, CF440 |
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00055 | Biotium | 300U | EUR 449 |
Description: Minimum order quantity: 1 unit of 300U |
![]() Phalloidin, CF440 |
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00055-T | Biotium | 50U | EUR 139 |
Description: Minimum order quantity: 1 unit of 50U |
![]() Cholera Toxin Subunit B, CF488A conjugate |
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00070 | Biotium | 100ug | EUR 261 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF568 conjugate |
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00071 | Biotium | 100ug | EUR 261 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF594 conjugate |
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00072 | Biotium | 100ug | EUR 261 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF640R conjugate |
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00073 | Biotium | 100ug | EUR 264 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF532 conjugate |
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00074 | Biotium | 100ug | EUR 264 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF543 conjugate |
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00075 | Biotium | 100ug | EUR 264 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF620R conjugate |
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00076 | Biotium | 100ug | EUR 264 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF633 conjugate |
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00077 | Biotium | 100ug | EUR 264 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF660R conjugate |
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00078 | Biotium | 100ug | EUR 264 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Cholera Toxin Subunit B, CF680R conjugate |
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00079 | Biotium | 100ug | EUR 282 |
Description: Minimum order quantity: 1 unit of 100ug |
![]() Human Transferrin, CF488A conjugate |
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00081 | Biotium | 1mg | EUR 149 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() Human Transferrin, CF543 conjugate |
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00082 | Biotium | 1mg | EUR 149 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() Human Transferrin, CF568 conjugate |
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00083 | Biotium | 1mg | EUR 149 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() Human Transferrin, CF594 conjugate |
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00084 | Biotium | 1mg | EUR 149 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() Human Transferrin, CF640R conjugate |
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00085 | Biotium | 1mg | EUR 149 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() Human Transferrin, CF680R conjugate |
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00086 | Biotium | 1mg | EUR 149 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() Human Transferrin, CF750 conjugate |
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00087 | Biotium | 1mg | EUR 155 |
Description: Minimum order quantity: 1 unit of 1mg |
![]() HIV-1 tat recombinant antigen |
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00110-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HIV-1 tat recombinant antigen full length 15 kDa |
![]() HIV-1 tat recombinant antigen |
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00110-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HIV-1 tat recombinant antigen full length 15 kDa |
![]() HIV-1 GAG P24 Recombinant Antigen |
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00111-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
![]() HIV-1 GAG P24 Recombinant Antigen |
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00111-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
![]() HIV-1 nef recombinant antigen |
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00112-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
![]() HIV-1 nef recombinant antigen |
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00112-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
![]() HIV-1 env gp41 recombinant antigen |
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00113-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
![]() HIV-1 env gp41 recombinant antigen |
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00113-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
![]() HIV-2 GP 36 Recombinant Antigen |
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00114-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
![]() HIV-2 GP 36 Recombinant Antigen |
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00114-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
![]() HCV core recombinant antigen |
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00115-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
![]() HCV core recombinant antigen |
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00115-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
![]() HCV core recombinant antigen, Biotin conjugate |
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00115-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
![]() HCV core recombinant antigen, Biotin conjugate |
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00115-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
![]() HCV core recombinant antigen, FITC conjugate |
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00115-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
![]() HCV core recombinant antigen, FITC conjugate |
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00115-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
![]() HCV core recombinant antigen, Rhodamine |
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00115-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
![]() HCV core recombinant antigen, Rhodamine |
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00115-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
![]() HCV NS4 recombinant antigen NS4a+b |
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00116-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
![]() HCV NS4 recombinant antigen NS4a+b |
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00116-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
![]() HCV NS4 recombinant antigen NS4a+b, Biotin |
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00116-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
![]() HCV NS4 recombinant antigen NS4a+b, Biotin |
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00116-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
![]() HCV NS4 recombinant antigen NS4a+b, FITC |
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00116-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
![]() HCV NS4 recombinant antigen NS4a+b, FITC |
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00116-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
![]() HCV NS4 recombinant antigen NS4a+b, Rhodamine |
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00116-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
![]() HCV NS4 recombinant antigen NS4a+b, Rhodamine |
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00116-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
![]() HCV NS3 recombinant antigen |
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00117-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
![]() HCV NS3 recombinant antigen |
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00117-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
![]() HBV core recombinant antigen |
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00120-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
![]() HBV core recombinant antigen |
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00120-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
![]() HBV core recombinant antigen, Delta |
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00121-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
![]() HBV core recombinant antigen, Delta |
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00121-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
![]() HBV surface recombinant antigen HBsAg |
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00122-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
![]() HBV surface recombinant antigen HBsAg |
|||
00122-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
![]() HBV surface recombinant antigen HBsAg antigen |
|||
00123-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
![]() HBV surface recombinant antigen HBsAg antigen |
|||
00123-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
![]() HBV surface recombinant antigen HBsAg antigen |
|||
00124-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
![]() HBV surface recombinant antigen HBsAg antigen |
|||
00124-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
![]() HEV (Birma) ORF2 recombinant antigen |
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00131-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
![]() HEV (Birma) ORF2 recombinant antigen |
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00131-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
![]() HEV (Birma) ORF2 recombinant antigen |
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00132-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
![]() HEV (Birma) ORF2 recombinant antigen |
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00132-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
![]() AA 403-461 HEV Birma ORF2 Recombinant Antigen |
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00133-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
![]() AA 403-461 HEV Birma ORF2 Recombinant Antigen |
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00133-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
![]() T, Pallidum recombinant antigen p15 |
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00141-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: T. Pallidum recombinant antigen p15 (full length) |
![]() T, Pallidum recombinant antigen p15 |
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00141-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: T. Pallidum recombinant antigen p15 (full length) |
![]() T, Pallidum recombinant antigen p17 |
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00142-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: T. Pallidum recombinant antigen p17 (full length) |
![]() T, Pallidum recombinant antigen p17 |
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00142-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: T. Pallidum recombinant antigen p17 (full length) |
![]() T, Pallidum recombinant antigen p45 |
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00143-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: T. Pallidum recombinant antigen p45 (full length) |
![]() T, Pallidum recombinant antigen p45 |
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00143-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: T. Pallidum recombinant antigen p45 (full length) |
![]() T, pallidum recombinant antigen TmpA |
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00144-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: T. Pallidum recombinant antigen TmpA (full length) |
![]() T, pallidum recombinant antigen TmpA |
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00144-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: T. Pallidum recombinant antigen TmpA (full length) |
![]() HCV core 2-119aa recombinant antigen |
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00150-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
![]() HCV core 2-119aa recombinant antigen |
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00150-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
![]() HCV Core 24 Antigen |
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00151-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
Description: HCV core 24 antigen. |
![]() HCV Core 24 Antigen |
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00151-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
Description: HCV core 24 antigen. |
The main operate of vitamin D is to take care of calcium homeostasis. It accomplishes this by growing the effectivity of the gut to soak up dietary calcium. When there’s insufficient calcium in the food plan to fulfill the physique’s calcium requirement, vitamin D communicates to the osteoblasts that sign osteoclast precursors to mature and dissolve the calcium saved in the bone. The typical “vitamin D-deficiency” dysfunction was noticed for rising youngsters in the west and south of England in the early 1600s. This illness was described by Glisson and named “rickets” (recognized additionally as “the English illness”) and was noticed with epidemic proportions in northern Europe and North America. The corrections of deformities of rickets have been at the origin of the title “orthopedia” and of the approach of osteotomies.