Decoding neuronal composition and ontogeny of individual hypothalamic nuclei

Decoding neuronal composition and ontogeny of individual hypothalamic nuclei

The hypothalamus performs essential roles in regulating endocrine, autonomic, and behavioral features by way of its numerous nuclei and neuronal subtypes. The developmental mechanisms underlying ontogenetic institution of completely different hypothalamic nuclei and era of neuronal range stay largely unknown. Here, we present that combinatorial T-box 3 (TBX3), orthopedia homeobox (OTP), and distal-less homeobox (DLX) expression delineates all arcuate nucleus (Arc) neurons and defines 4 distinct subpopulations, whereas combinatorial NKX2.1/SF1 and OTP/DLX expression identifies ventromedial hypothalamus (VMH) and tuberal nucleus (TuN) neuronal subpopulations, respectively.

Developmental evaluation signifies that every one 4 Arc subpopulations are mosaically and concurrently generated from embryonic Arc progenitors, whereas glutamatergic VMH neurons and GABAergic TuN neurons are sequentially generated from frequent embryonic VMH progenitors. Moreover, clonal lineage-tracing evaluation reveals that numerous lineages from multipotent radial glia progenitors orchestrate Arc and VMH-TuN institution. Together, our research reveals mobile mechanisms underlying era and group of numerous neuronal subtypes and ontogenetic institution of individual nuclei within the mammalian hypothalamus.

The Drosophila hindgut is often used mannequin for learning numerous points of organogenesis like primordium institution, additional specification, patterning, and morphogenesis. During embryonic growth of Drosophila, many transcriptional activators are concerned within the formation of the hindgut. The transcription issue Orthopedia (Otp), a member of the 57B homeobox gene cluster, is expressed within the hindgut and nervous system of creating Drosophila embryos, however as a result of lack of mutants no useful evaluation has been carried out but.
We present that two completely different otp transcripts, a hindgut-specific and a nervous system-specific kind, are current within the Drosophila embryo. Using an Otp antibody, an in depth expression evaluation throughout hindgut growth was carried out. Otp was not solely expressed within the embryonic hindgut, but additionally within the larval and grownup hindgut. To analyse the operate of otp, we generated the mutant otp allele otpGT by ends-out gene concentrating on. In addition, we remoted two EMS-induced otp alleles in a genetic display screen for mutants of the 57B area.
All three otp alleles confirmed embryonic lethality with a extreme hindgut phenotype. Anal pads have been lowered and the big gut was utterly lacking. This phenotype is because of apoptosis within the hindgut primordium and the creating hindgut. Our information recommend that Otp is one other essential issue for hindgut growth of Drosophila. As a downstream issue of byn Otp is probably current solely in differentiated hindgut cells throughout all phases of growth moderately than in stem cells.

Orthopedia Homeobox (OTP) in Pulmonary Neuroendocrine Tumors: The Diagnostic Value and Possible Molecular Interactions.

 

Generally, sufferers with stage I-IIIa (TNM) pulmonary carcinoid illness have a beneficial prognosis after healing resection. Yet, distant recurrence of illness after healing surgical procedure happens in roughly 1-6% of sufferers with typical carcinoid and 14-29% in sufferers with atypical carcinoid illness, respectively. Known predictors of distant recurrence of illness are atypical carcinoid, lymphatic involvement, and incomplete resection standing.

However, none of them might be reliably used, alone or together, to exclude sufferers from long-term follow-up (suggested 15 years). By genomic profiling, Orthopedia homeobox (OTP) has been recognized as a promising prognostic marker for pulmonary carcinoid with a beneficial prognosis and low danger of distant illness recurrence. Moreover, OTP is a extremely particular marker for carcinoids of pulmonary origin and current genome large evaluation has recognized OTP as a vital predictor of aggressive tumor behaviour.

OTP together with CD44, a stem cell marker and cell-surface protein, permits the identification of sufferers with surgical resected carcinoid illness that might doubtlessly be excluded from long-term follow-up. In future scientific observe OTP might allow clinicians to scale back the diagnostic burden and associated misery and scale back prices of long-term radiological assessments in sufferers with a pulmonary carcinoid. This overview addresses the present scientific worth of OTP and the potential molecular mechanisms regulating OTP expression and operate in pulmonary carcinoids.

Decoding neuronal composition and ontogeny of individual hypothalamic nuclei

The C-terminus of the retinal homeobox (rax) gene product modulates transcription in a context-dependent method.

 

The evolutionarily conserved retinal homeobox (Rax) transcription issue is important for regular eye growth in all vertebrates. Despite Rax’s biologic significance, the molecular mechanisms underlying Rax molecular operate as a transcriptional regulator are poorly outlined. The rax gene encodes a conserved octapeptide motif (OP) close to the N-terminus and a number of conserved areas within the C-terminus of unknown operate, together with the orthopedia, aristaless, rax (OAR) area and the RX area. The goal of this research is to analyze the contribution of these conserved domains in Rax operate.

N-and C-terminal deletion and level mutations have been generated in Xenopus laevis rax.L (beforehand generally known as Rx1A) utilizing PCR-based strategies. We examined the flexibility of mutated Rax to transactivate a reporter gene consisting of a portion of a rax goal gene promoter (from the Xenopus rhodopsin gene) fused to a firefly luciferase coding area and transfected into human embryonic kidney 293T (HEK293T) cells. Portions of the Rax C-terminal area have been additionally assayed for transactivation exercise within the context of a heterologous DNA binding area with an applicable reporter gene.

Full-length Rax weakly activated the reporter. Deletion of the Rax C-terminus elevated Rax exercise, suggesting that the C-terminus features to repress Rax exercise. Further deletion finally resulted in a lower in exercise, suggesting that the C-terminal area can also operate to reinforce Rax exercise. Deletion or mutation of the OP motif resulted in a slight lower in Rax exercise. Mutation or deletion of the N-terminal OP motif resulted in a gentle lower in exercise and dampened the exercise ranges of the C-terminal deletions. Further, fusion of the C-terminus of Rax to a heterologous DNA binding area enhanced transactivation.

Alpha-bungarotoxin, CF680r

9-00003
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r

9-00004
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r

9-00004
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a

9-00005
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a

9-00005
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568

9-00006
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568

9-00006
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594

9-00007
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594

9-00007
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633

9-00009
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633

9-00009
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin

00010-1 1MG
EUR 168
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin

00011 500uG
EUR 367
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin

00012 500uG
EUR 383
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)

00013 10ST
EUR 417
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)

00014 10ST
EUR 466
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)

00015 500uG
EUR 466
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)

00016 10ST
EUR 523
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin

00017 500uG
EUR 433
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:

00020 1MG
EUR 314
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)

00020-1 20ST
EUR 418
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:

00021 1MG
EUR 344
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)

00021-1 20ST
EUR 448
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:

00022 1MG
EUR 491
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)

00022-1 20ST
EUR 625
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:

00023 1MG
EUR 281
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine

00025 100uG
EUR 139
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543

00026 500uG
EUR 494
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u

00027 300
EUR 345
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin

00028 100U
EUR 428
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin

00030 300U
EUR 345
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin

00032 300ST
EUR 345
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin

00033 300EU
EUR 345
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M

00034 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M

00034-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP

00036 100ug
EUR 172
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP

00037 100ug
EUR 172
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555

00040 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647

00041 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647

00041-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A

00042 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A

00042-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543

00043 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543

00043-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568

00044 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568

00044-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594

00045 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594

00045-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633

00046 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633

00046-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R

00047 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R

00047-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R

00048 300U
EUR 466
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R

00048-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350

00049 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350

00049-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R

00050 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R

00050-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532

00051 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532

00051-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C

00052 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C

00052-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680

00053 300U
EUR 466
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680

00053-T 50U
EUR 147
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430

00054 300U
EUR 449
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430

00054-T 50U
EUR 139
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440

00055 300U
EUR 449
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440

00055-T 50U
EUR 139
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate

00070 100ug
EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate

00071 100ug
EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate

00072 100ug
EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate

00073 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate

00074 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate

00075 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate

00076 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate

00077 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate

00078 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate

00079 100ug
EUR 282
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate

00081 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate

00082 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate

00083 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate

00084 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate

00085 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate

00086 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF750 conjugate

00087 1mg
EUR 155
Description: Minimum order quantity: 1 unit of 1mg

HIV-1 tat recombinant antigen

00110-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen

00110-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 nef recombinant antigen

00112-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen

00112-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen

00113-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen

00113-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-2 GP 36 Recombinant Antigen

00114-V-01mg 0,1 mg
EUR 267.5
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen

00114-V-1000ug 1000 ug
EUR 1282.5
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HCV core recombinant antigen

00115-V-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen

00115-V-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen, Biotin conjugate

00115-V-B-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, Biotin conjugate

00115-V-B-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, FITC conjugate

00115-V-F-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, FITC conjugate

00115-V-F-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, Rhodamine

00115-V-R-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV core recombinant antigen, Rhodamine

00115-V-R-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b

00116-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b

00116-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b, Biotin

00116-V-B-01mg 0,1 mg
EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, Biotin

00116-V-B-1000ug 1000 ug
EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC

00116-V-F-01mg 0,1 mg
EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC

00116-V-F-1000ug 1000 ug
EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine

00116-V-R-01mg 0,1 mg
EUR 267.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine

00116-V-R-1000ug 1000 ug
EUR 1282.5
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS3 recombinant antigen

00117-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HCV NS3 recombinant antigen

00117-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HBV core recombinant antigen

00120-V-01mg 0,1 mg
EUR 267.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen

00120-V-1000ug 1000 ug
EUR 1282.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen, Delta

00121-V-01mg 0,1 mg
EUR 267.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV core recombinant antigen, Delta

00121-V-1000ug 1000 ug
EUR 1282.5
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV surface recombinant antigen HBsAg

00122-V-01mg 0,1 mg
EUR 267.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg

00122-V-1000ug 1000 ug
EUR 1282.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg antigen

00123-V-01mg 0,1 mg
EUR 267.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen

00123-V-1000ug 1000 ug
EUR 1282.5
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen

00124-V-01mg 0,1 mg
EUR 267.5
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant

HBV surface recombinant antigen HBsAg antigen

00124-V-1000ug 1000 ug
EUR 1282.5
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant

HEV (Birma) ORF2 recombinant antigen

00131-V-01mg 0,1 mg
EUR 267.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659.

HEV (Birma) ORF2 recombinant antigen

00131-V-1000ug 1000 ug
EUR 1282.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659.

HEV (Birma) ORF2 recombinant antigen

00132-V-01mg 0,1 mg
EUR 267.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461.

HEV (Birma) ORF2 recombinant antigen

00132-V-1000ug 1000 ug
EUR 1282.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461.

AA 403-461 HEV Birma ORF2 Recombinant Antigen

00133-V-01mg 0,1 mg
EUR 267.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123.

AA 403-461 HEV Birma ORF2 Recombinant Antigen

00133-V-1000ug 1000 ug
EUR 1282.5
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123.

T, Pallidum recombinant antigen p15

00141-V-01mg 0,1 mg
EUR 267.5
Description: T. Pallidum recombinant antigen p15 (full length)

T, Pallidum recombinant antigen p15

00141-V-1000ug 1000 ug
EUR 1282.5
Description: T. Pallidum recombinant antigen p15 (full length)

T, Pallidum recombinant antigen p17

00142-V-01mg 0,1 mg
EUR 267.5
Description: T. Pallidum recombinant antigen p17 (full length)

T, Pallidum recombinant antigen p17

00142-V-1000ug 1000 ug
EUR 1282.5
Description: T. Pallidum recombinant antigen p17 (full length)

T, Pallidum recombinant antigen p45

00143-V-01mg 0,1 mg
EUR 267.5
Description: T. Pallidum recombinant antigen p45 (full length)

T, Pallidum recombinant antigen p45

00143-V-1000ug 1000 ug
EUR 1282.5
Description: T. Pallidum recombinant antigen p45 (full length)

T, pallidum recombinant antigen TmpA

00144-V-01mg 0,1 mg
EUR 267.5
Description: T. Pallidum recombinant antigen TmpA (full length)

T, pallidum recombinant antigen TmpA

00144-V-1000ug 1000 ug
EUR 1282.5
Description: T. Pallidum recombinant antigen TmpA (full length)

HCV core 2-119aa recombinant antigen

00150-V-01mg 0,1 mg
EUR 267.5
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a

HCV core 2-119aa recombinant antigen

00150-V-1000ug 1000 ug
EUR 1282.5
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a

HCV Core 24 Antigen

00151-V-01mg 0,1 mg
EUR 267.5
Description: HCV core 24 antigen.

HCV Core 24 Antigen

00151-V-1000ug 1000 ug
EUR 1282.5
Description: HCV core 24 antigen.

HCV core recombinant antigen

00152-V-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a.105-302

HCV core recombinant antigen

00152-V-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a.105-302

HCV NS3 1192-1456 aa Recombinant Antigen

00153-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a

HCV NS3 1192-1456 aa Recombinant Antigen

00153-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a

HCV NS3 1359-1456aa antigen

00154-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6

HCV NS3 1359-1456aa antigen

00154-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6

HCV NS4 mosaic recombinant antigen

00155-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5.

HCV NS4 mosaic recombinant antigen

00155-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5.

HCV NS4 1916-1947aa recombinant antigen

00156-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS4 1916-1947aa recombinant antigen.

HCV NS4 1916-1947aa recombinant antigen

00156-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS4 1916-1947aa recombinant antigen.

HCV NS5 2061-2302aa recombinant antigen

00157-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS5 2061-2302aa recombinant antigen.

HCV NS5 2061-2302aa recombinant antigen

00157-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS5 2061-2302aa recombinant antigen.

HCV NS5 2212-2313aa recombinant antigen

00158-V-01mg 0,1 mg
EUR 267.5
Description: HCV NS5 2212-2313aa recombinant antigen. Available genotypes: 1a, 1b, 2a, 2b, 3a, 3b, 4, 5, 6a.

HCV NS5 2212-2313aa recombinant antigen

00158-V-1000ug 1000 ug
EUR 1282.5
Description: HCV NS5 2212-2313aa recombinant antigen. Available genotypes: 1a, 1b, 2a, 2b, 3a, 3b, 4, 5, 6a.

HAV VP1-P2A recombinant antigen

00159-V-01mg 0,1 mg
EUR 267.5
Description: HAV VP1-P2A recombinant antigen a.a. 722-830.

HAV VP1-P2A recombinant antigen

00159-V-1000ug 1000 ug
EUR 1282.5
Description: HAV VP1-P2A recombinant antigen a.a. 722-830.

HAV VP4-VP2 recombinant antigen

00160-V-01mg 0,1 mg
EUR 267.5
Description: HAV VP4-VP2 recombinant antigen a.a. 55-164.

HAV VP4-VP2 recombinant antigen

00160-V-1000ug 1000 ug
EUR 1282.5
Description: HAV VP4-VP2 recombinant antigen a.a. 55-164.

HAV P2C-P3A recombinant antigen

00161-V-01mg 0,1 mg
EUR 267.5
Description: HAV P2C-P3A recombinant antigen a.a. 1492-1606.

HAV P2C-P3A recombinant antigen

00161-V-1000ug 1000 ug
EUR 1282.5
Description: HAV P2C-P3A recombinant antigen a.a. 1492-1606.

The current information point out that the C-terminus of Rax can operate to repress or activate transcription in a context-dependent method. These information help our speculation that the extremely conserved OAR area, together with different regulatory components within the Rax C-terminus, coordinates Rax exercise, maybe by useful interplay with the N-terminal OP motif. Taken collectively, these information present perception into the structural options that regulate Rax exercise.