Prognostic Significance of CD44 and Orthopedia Homeobox Protein (OTP) Expression in Pulmonary Carcinoid Tumours.

CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to a tertiary cancer centre diagnosed with PC between 2003 and 2015.

Diagnosis was confirmed by central pathology review. Formalin-fixed paraffin-embedded (FFPE) tissue samples collected at diagnosis were scored using immunohistochemistry (H score) for standard CD44 and nuclear and cytoplasmic OTP protein expression.

The study included 108 patients. High CD44/nuclear OTP (nOTP) expression was strongly associated with typical carcinoid (TC) histology (p < 0.001). Eighty-six patients, who underwent radical surgical resection, were selected to assess the impact of patient and tumour parameters on relapse-free survival (RFS). Sixty-nine (80 %) had TC and 17 (20 %) had atypical carcinoid tumours. On multivariate analysis, high CD44 and nOTP expression, TC histology and non-infiltrative tumour growth were associated with superior RFS. Early stage TC (stage pT1aN0) patients (N = 32; 46 %) had excellent prognosis irrespective of CD44/nOTP status.

Endothelin-1 (1-15), amide, human
A1111-1	ApexBio	1 mg	EUR 722
Description: Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis.

CMPD-1
B2991-1	Biovision	1mg	EUR 125

TAPI-1
2068-1	Biovision		EUR 398

IDE-1
2193-1	Biovision		EUR 147

PFI-1
2203-1	Biovision		EUR 115

IQ-1
1663-1	Biovision		EUR 204

Shz-1
1915-1	Biovision		EUR 137

1-Azakenpaullone
1944-1	Biovision		EUR 289

StemRegenin 1
1967-1	Biovision		EUR 147

SANT-1
1978-1	Biovision		EUR 126

4EGI-1
B2901-1	Biovision		EUR 142

UK 1
C5006-1	ApexBio	1 mg	EUR 363
Description: UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication.

KP372-1
C5053-1	ApexBio	1 mg	EUR 132
Description: IC50: 30-60 nM for thyroid cancer cells KP372-1 is a specific Akt inhibitor. The phosphatidylinositol 3' kinase (PI3K)/phosphatase, which is a key regulator of cell proliferation and survival, is mutated or activated in various cancers.

IDE 1
B7566-1	ApexBio	1 mg	EUR 118

Rbin-1
B7823-1	ApexBio	1 mg	EUR 154
Description: Rbin-1 is an eukaryotic ribosome assembly inhibitor.All cellular proteins are synthesized by ribosomes, whose biogenesis is a complex multi-step process quickly completed in eukaryotes.

TAPI-1
B4686-1	ApexBio	1 mg	EUR 268
Description: TAPI-1 is an inhibitor of tumour necrosis factor with IC50 value of 8.09 ?M [1].TAPI-1 is an inhibitor of TACE/ADAM17 which catalyzes the cleavage of full-length APP to the soluble N-terminal fragment (sAPP?).

C14TKL-1
B5240-1	ApexBio	1 mg	EUR 399

?1-MSH
B5427-1	ApexBio	1 mg	EUR 268

MMK 1
B5446-1	ApexBio	1 mg	EUR 268

CRSP-1
B5452-.1	ApexBio	100 ug	EUR 415

ADWX 1
B5722-.1	ApexBio	100 ug	EUR 583
Description: ADWX 1 is a potent and selective inhibitor of KV1.3 channel with IC50 values of 1.89 pM and 0.65 nM for Kv1.3 and Kv1.1, respectively [1].

Purotoxin 1
B5771-.1	ApexBio	100 µg	EUR 380

Shz 1
B5772-1	ApexBio	1 mg	EUR 118

Psalmotoxin 1
B5796-.1	ApexBio	100 ug	EUR 447
Description: IC50: 0.9 nMPsalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.Several ASIC subunits described: ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 with different kinetics, tissue distribution, and external pH sensitivities.

Flutax 1
B6986-1	ApexBio	1 mg	EUR 399

Anti-HO-1 Monoclonal Antibody (HO-1-2)
M00253-1	BosterBio	1mg	EUR 397
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat.

IL-1-beta Interleukin-1 betaHuman Recombinant Protein
PROTP01584-1	BosterBio	Regular: 10ug	EUR 317
Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques.

MMP-1 Matrix Metalloproteinase-1 Human Recombinant Protein
PROTP03956-1	BosterBio	Regular: 20ug	EUR 317
Description: MMP 1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (100-469a.a) and having a molecular mass of 45kDa. MMP 1 is fused to a 23 amino acid His-tag at N-terminus.

EZSolution? TAPI-1
2537-1	Biovision		EUR 381

(R)-Perharidine-1
2615-1	Biovision		EUR 164

Akt-I-1
B1610-1	Biovision		EUR 185

TASIN-1 hydrochloride
B2088-1	Biovision		EUR 142

1-NM-PP1
B2346-1	Biovision		EUR 142

Teicoplanin A3-1
C4943-1	ApexBio	1 mg	EUR 326
Description: Teicoplanin A3-1, also known as Antibiotic L 17054, is a glycopeptide antibiotic derived from Actinoplanes teichomyceticus and produces a potent broad spectrum antibiotic activity against gram-positive bacteria.

SL 0101-1
B9008-1	ApexBio	1 mg	EUR 163

CDK7-IN-1
B4665-1	ApexBio	1 mg	EUR 358

LPA2 antagonist 1
B4726-1	ApexBio	1 mg	EUR 319

PACAP 1-27
B5075-1	ApexBio	1 mg	EUR 290

Nociceptin (1-7)
B5087-1	ApexBio	1 mg	EUR 399

Hemokinin 1 (mouse)
B5127-1	ApexBio	1 mg	EUR 321

GIP (1-39)
B5280-1	ApexBio	1 mg	EUR 609

JMV 390-1
B5317-1	ApexBio	1 mg	EUR 242

Hemokinin 1 (human)
B5318-1	ApexBio	1 mg	EUR 340

Echistatin, ?1 isoform
B5391-.1	ApexBio	100 ug	EUR 583

HPGDS inhibitor 1
B1046-1	ApexBio	1 mg	EUR 181
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation.

StemRegenin 1 (hydrochloride)
C3551-1	ApexBio	1 mg	EUR 118
Description: IC50: 127 nM in CD34+ cellsStemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist.The aryl hydrocarbon receptor (AhR ) is a protein that is encoded by the AHR gene.

RN-1 (hydrochloride)
C4247-1	ApexBio	1 mg	EUR 112
Description: RN-1 (hydrochloride) is a brain-penetrant, potent and irreversible LSD1 inhibitor with IC50 values of 10-70 nM [1]. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9.

PACAP 1-38
B6625-1	ApexBio	1 mg	EUR 347

Sphingosine-1-phosphate
B6707-1	ApexBio	1 mg	EUR 181
Description: Sphingosine-1-phosphate is an endogenous second messenger that involved in cell proliferation and survival and is a ligand for S1PR1 [1] [2].

IDO-IN-1
C3211-1	ApexBio	1 mg	EUR 139
Description: IC50: 59 nMIDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor.

(1-328) RAD51D (1-328 a.a.) Human Recombinant Protein
PROTO75771-1	BosterBio	Regular: 10ug	EUR 317
Description: RAD51D (1-328) Human Recombinant produced in E. coli is. a single polypeptide chain containing 351 amino acids and having a molecular mass of 37.4kDa. RAD51D (1-328) is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

XMIR-1 RNA oligo miRNA-1-3p with Xmotif
XMIR-1	SBI	10 rxn	EUR 438

Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EI2200-1	AssayPro	96 Well Plate	EUR 477

Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit
EI2301-1	AssayPro	96 Well Plate	EUR 477

Human KRAB-associated Protein 1 (KAP-1) AssayMax ELISA Kit
EK2802-1	AssayPro	96 Well Plate	EUR 477

Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit
EMI2200-1	AssayPro	96 Well Plate	EUR 477

Human Plasminogen Activator Inhibitor-1 (PAI-1) AssayMax ELISA Kit
EP1100-1	AssayPro	96 Well Plate	EUR 417

GAD1 iso1 Glutamate Decarboxylase 1 Isoform-1 Human Recombinant Protein
PROTQ99259-1	BosterBio	Regular: 20ug	EUR 317
Description: GAD1 iso1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 617 amino acids (1-594 a.a) and having a molecular mass of 69.3kDa. GAD1 iso1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378
M04431-1	BosterBio	100uL	EUR 385
Description: Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 tested in WB, IHC, reactive to Human

TGF-b-1 Transforming Growth Factor-beta 1 Human protein
PROTP01137-1	BosterBio	Regular: 2.5ug	EUR 1157
Description: Human Transforming Growth Factor-beta 1 purified from Human Platelets having a molecular mass of 25kDa.;The TGF-b 1 is purified by proprietary chromatographic techniques.

MCP-1 Monocyte Chemotactic Protein-1 Mouse Recombinant Protein (CCL2)
PROTP10148-1	BosterBio	Regular: 10ug	EUR 317
Description: Monocyte Chemotactic Protein-1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa. ;The MCP-1 is purified by proprietary chromatographic techniques.

MCP-1 Monocyte Chemotactic Protein-1 Human Recombinant Protein (CCL2)
PROTP13500-1	BosterBio	Regular: 20ug	EUR 317
Description: Monocyte Chemotactic Protein-1 Human Recombinant also known as Monocyte Chemotactic and Activating Factor (MCAF) produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8.6kDa. ;The MCP-1 is purified by proprietary chromatographic techniques.

Envelope-1, Dengue Virus Subtype 1 Recombinant Protein, Insect Cells
PROTB1PNJ5-1	BosterBio	Regular: 10ug	EUR 317
Description: Recombinant Dengue Virus Subtype 1 produced in Insect Cells is a polypeptide chain containing amino acids 281-675 and having a molecular weight of approximately 50kDa. ;Dengue Envelope-1 is purified by proprietary chromatographic technique.

AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif
AXMIR-1	SBI	10 reactions	EUR 438

dNTP Mix (1 ml)
9002-1	Biovision		EUR 153

Individual Reaction Mix 1
G065-1	ABM	200 reactions	EUR 167

StemRegenin 1, Free base
2642-1	Biovision		EUR 131

Anti-PARP-1 Antibody
A00122-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-Presenilin 1 Antibody
A00138-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-PAI-1 Antibody
A00637-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat.

Anti-Flk-1 Antibody
A00901-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse.

Anti-EDG-1 Antibody
A01502-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat.

Anti-ROBO-1 Antibody
A01530-1	BosterBio	100ug	EUR 455
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-TFIIIB90-1 Antibody
A03761-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse.

Anti-Atrophin-1 Antibody
A03828-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-CNG-1 Antibody
A05494-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Periphilin 1 Antibody
A06996-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse.

Anti-Lyl-1 Antibody
A07491-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLI-1 Antibody
A07972-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Cerebellin 1 Antibody
A09176-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-DOC-1 Antibody
A09467-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse.

Anti-Bag-1 Antibody
A02423-1	BosterBio	50 ul	EUR 397
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat.

Anti-TUB 1 Antibody
A02917-1	BosterBio	100ug/vial	EUR 294

Anti-Dok-1 Antibody
A03039-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat.

Anti-NPDC-1 Antibody
A12846-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat.

Bovine LIVER 1 EA*
57123-1	Pel-Freez	1 Each	EUR 180.28

Supercoiled pHOT-1 DNA
TG2030-1	TopoGen	25 ug	EUR 246

Relaxed pHOT-1 DNA
TG2035-1	TopoGen	25 ug	EUR 246

Beta-Amyloid (1-11)
A1002-1	ApexBio	1 mg	EUR 102
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

Amyloid ?-Protein (1-15)
A1003-1	ApexBio	1 mg	EUR 113
Description: Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.

ANP (1-11), rat
A1009-1	ApexBio	1 mg	EUR 84
Description: Atrial Natriuretic Peptide (ANP) (C49H84N20O15S) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide that is synthesized, stored, and released by atrial myocytes in response to atrial distension, endothelin, and sympathetic stimulation.

alpha-1 antitrypsin fragment
A1051-1	ApexBio	1 mg	EUR 108
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

BNP (1-32), human
A1105-1	ApexBio	1 mg	EUR 177
Description: Basic natriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP) or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

B-Raf IN 1
B4727-1	ApexBio	1 mg	EUR 118

Nociceptin (1-13)NH2
B5102-1	ApexBio	1 mg	EUR 184

JIP-1 (153-163)
B5130-1	ApexBio	1 mg	EUR 399

Nogo-66 (1-40)
B5247-1	ApexBio	1 mg	EUR 609

Orphanin FQ (1-11)
B5497-1	ApexBio	1 mg	EUR 226

R-1 Methanandamide Phosphate
C3352-1	ApexBio	1 mg	EUR 126
Description: R-1 Methanandamide Phosphate,a water soluble prodrug analog of AEA, exhibited similar activity to that of AEA in the growth inhibition of C6 glioma cells[1]. Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB).

Ginkgolic Acid C15:1
C3421-1	ApexBio	1 mg	EUR 118
Description: Ginkgolic acid is an alkylphenol derivative that causes allergic skin inflammation. IC50 values of ginkgolic acid against the SUMOylation of RanGAP1-C2 are 3.0 ?M. Ginkgolic Acid, a Major Component of Ginkgo biloba Extract, inhibited SUMOylation in vitro and in vivo [1].

IGF-1, human recombinant
P1016-.1	ApexBio	100 µg	EUR 763
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

Human Heat Shock Factor Protein 1 (HSF 1) AssayMax ELISA kit
EH5215-1	AssayPro	96 Well Plate	EUR 417

Human Insulin-like Growth Factor 1 (IGF-1) AssayMax ELISA Kit
EI1001-1	AssayPro	96 Well Plate	EUR 477

Mouse Insulin-like Growth Factor 1 (IGF-1) AssayMax ELISA Kit
EMI1001-1	AssayPro	96 Well Plate	EUR 477

VAMP2 (1-94) Synaptobrevin-2 (1-94 a.a) Human Recombinant Protein
PROTP63027-1	BosterBio	Regular: 5ug	EUR 317
Description: VAMP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-94 a.a) and having a molecular mass of 12.8kDa.;VAMP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

IL1RL1 Human, Interleukin-1 Receptor Like-1 Human Recombinant Protein, Sf9
PROTQ01638-1	BosterBio	Regular: 10ug	EUR 317
Description: IL 1RL1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (19-328 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 318 amino acids and having a molecular mass of 36.0kDa.;IL 1RL1 shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

DCTN2 (1-406) Dynactin 2 (1-406 a.a.) Human Recombinant Protein
PROTQ13561-1	BosterBio	Regular: 20ug	EUR 317
Description: Dynactin 2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 429 amino acids (1-406 a.a) and having a molecular mass of 47.2kDa.;DCTN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

STX1A (1-265) Syntaxin-1A (1-265 a.a) Human Recombinant Protein
PROTQ16623-1	BosterBio	Regular: 10ug	EUR 317
Description: STX1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-265 a.a) and having a molecular mass of 30.7kDa.

GLP-1 Glucagon Like Peptide-1 (31 a.a.) Human Recombinant Protein
PROTP01275-1	BosterBio	Regular: 50ug	EUR 317
Description: Glucagon Like Peptide-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 31 amino acids and having a molecular mass of 3298.7 Dalton. The GLP-1 is purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Mouse Recombinant Protein, His Tag
PROTP01582-1	BosterBio	Regular: 20ug	EUR 317
Description: IL 1 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.4kDa.;IL 1 alpha is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Importantly, TC patients with locally advanced disease (defined as>>pT1aN0) and high CD44/nOTP expression (N = 26; 38 %) had excellent RFS (p = 0.005) compared to those with the same stage but low CD44 and/or nOTP (N = 11; 16 %). Additionally, the combination of CD44/nOTP expression and tumour growth pattern led to a more accurate prognostic system compared to the established WHO classification of PC tumours (concordance index = 0.902 vs 0.811, respectively, p < 0.001). Assessment of CD44/nOTP expression combined with tumour growth pattern identifies clear groups with largely different prognosis. These findings provide important information on how patients with these resected cancers should be followed up.