CD44 and orthopedia homeobox protein (OTP) expressions have shown to be predictive of overall survival in pulmonary carcinoid (PC) tumours. The scope of the present study was to validate their role in PC patients and investigate potential application in clinical practice. Data was collected from patients presenting to a tertiary cancer centre diagnosed with PC between 2003 and 2015.
Diagnosis was confirmed by central pathology review. Formalin-fixed paraffin-embedded (FFPE) tissue samples collected at diagnosis were scored using immunohistochemistry (H score) for standard CD44 and nuclear and cytoplasmic OTP protein expression.
The study included 108 patients. High CD44/nuclear OTP (nOTP) expression was strongly associated with typical carcinoid (TC) histology (p < 0.001). Eighty-six patients, who underwent radical surgical resection, were selected to assess the impact of patient and tumour parameters on relapse-free survival (RFS). Sixty-nine (80 %) had TC and 17 (20 %) had atypical carcinoid tumours. On multivariate analysis, high CD44 and nOTP expression, TC histology and non-infiltrative tumour growth were associated with superior RFS. Early stage TC (stage pT1aN0) patients (N = 32; 46 %) had excellent prognosis irrespective of CD44/nOTP status.
Angiotensin 1/2 (1-8) amide |
A1055-1 |
ApexBio |
1 mg |
EUR 96 |
Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ACE (angiotensin converting enzyme), by removing a dipeptide. |
Endothelin-1 (1-15), amide, human |
A1111-1 |
ApexBio |
1 mg |
EUR 722 |
Description: Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis. |
Haptoglobin, (Phenotype 1-1) Human Plasma |
7536-1 |
Biovision |
|
EUR 321 |
TAPI-1 |
B4686-1 |
ApexBio |
1 mg |
EUR 268 |
Description: TAPI-1 is an inhibitor of tumour necrosis factor with IC50 value of 8.09 ?M [1].TAPI-1 is an inhibitor of TACE/ADAM17 which catalyzes the cleavage of full-length APP to the soluble N-terminal fragment (sAPP?). |
C14TKL-1 |
B5240-1 |
ApexBio |
1 mg |
EUR 399 |
?1-MSH |
B5427-1 |
ApexBio |
1 mg |
EUR 268 |
CRSP-1 |
B5452-.1 |
ApexBio |
100 ug |
EUR 415 |
ADWX 1 |
B5722-.1 |
ApexBio |
100 ug |
EUR 583 |
Description: ADWX 1 is a potent and selective inhibitor of KV1.3 channel with IC50 values of 1.89 pM and 0.65 nM for Kv1.3 and Kv1.1, respectively [1]. |
Purotoxin 1 |
B5771-.1 |
ApexBio |
100 µg |
EUR 380 |
Psalmotoxin 1 |
B5796-.1 |
ApexBio |
100 ug |
EUR 447 |
Description: IC50: 0.9 nMPsalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.Several ASIC subunits described: ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 with different kinetics, tissue distribution, and external pH sensitivities. |
UK 1 |
C5006-1 |
ApexBio |
1 mg |
EUR 363 |
Description: UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication. |
KP372-1 |
C5053-1 |
ApexBio |
1 mg |
EUR 132 |
Description: IC50: 30-60 nM for thyroid cancer cells KP372-1 is a specific Akt inhibitor. The phosphatidylinositol 3' kinase (PI3K)/phosphatase, which is a key regulator of cell proliferation and survival, is mutated or activated in various cancers. |
Flutax 1 |
B6986-1 |
ApexBio |
1 mg |
EUR 399 |
Rbin-1 |
B7823-1 |
ApexBio |
1 mg |
EUR 154 |
Description: Rbin-1 is an eukaryotic ribosome assembly inhibitor.All cellular proteins are synthesized by ribosomes, whose biogenesis is a complex multi-step process quickly completed in eukaryotes. |
Anti-HO-1 Monoclonal Antibody (HO-1-2) |
M00253-1 |
BosterBio |
1mg |
EUR 397 |
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat. |
IL-1-beta Interleukin-1 betaHuman Recombinant Protein |
PROTP01584-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques. |
MMP-1 Matrix Metalloproteinase-1 Human Recombinant Protein |
PROTP03956-1 |
BosterBio |
Regular: 20ug |
EUR 317 |
Description: MMP 1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (100-469a.a) and having a molecular mass of 45kDa. MMP 1 is fused to a 23 amino acid His-tag at N-terminus. |
TASIN-1 hydrochloride |
B2088-1 |
Biovision |
|
EUR 142 |
CDK7-IN-1 |
B4665-1 |
ApexBio |
1 mg |
EUR 358 |
LPA2 antagonist 1 |
B4726-1 |
ApexBio |
1 mg |
EUR 319 |
PACAP 1-27 |
B5075-1 |
ApexBio |
1 mg |
EUR 290 |
Nociceptin (1-7) |
B5087-1 |
ApexBio |
1 mg |
EUR 399 |
Hemokinin 1 (mouse) |
B5127-1 |
ApexBio |
1 mg |
EUR 321 |
GIP (1-39) |
B5280-1 |
ApexBio |
1 mg |
EUR 609 |
JMV 390-1 |
B5317-1 |
ApexBio |
1 mg |
EUR 242 |
Hemokinin 1 (human) |
B5318-1 |
ApexBio |
1 mg |
EUR 340 |
Echistatin, ?1 isoform |
B5391-.1 |
ApexBio |
100 ug |
EUR 583 |
HPGDS inhibitor 1 |
B1046-1 |
ApexBio |
1 mg |
EUR 181 |
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation. |
Teicoplanin A3-1 |
C4943-1 |
ApexBio |
1 mg |
EUR 326 |
Description: Teicoplanin A3-1, also known as Antibiotic L 17054, is a glycopeptide antibiotic derived from Actinoplanes teichomyceticus and produces a potent broad spectrum antibiotic activity against gram-positive bacteria. |
RN-1 (hydrochloride) |
C4247-1 |
ApexBio |
1 mg |
EUR 112 |
Description: RN-1 (hydrochloride) is a brain-penetrant, potent and irreversible LSD1 inhibitor with IC50 values of 10-70 nM [1]. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9. |
IDO-IN-1 |
C3211-1 |
ApexBio |
1 mg |
EUR 139 |
Description: IC50: 59 nMIDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor. |
StemRegenin 1 (hydrochloride) |
C3551-1 |
ApexBio |
1 mg |
EUR 118 |
Description: IC50: 127 nM in CD34+ cellsStemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist.The aryl hydrocarbon receptor (AhR ) is a protein that is encoded by the AHR gene. |
PACAP 1-38 |
B6625-1 |
ApexBio |
1 mg |
EUR 347 |
Sphingosine-1-phosphate |
B6707-1 |
ApexBio |
1 mg |
EUR 181 |
Description: Sphingosine-1-phosphate is an endogenous second messenger that involved in cell proliferation and survival and is a ligand for S1PR1 [1] [2]. |
SL 0101-1 |
B9008-1 |
ApexBio |
1 mg |
EUR 163 |
(1-328) RAD51D (1-328 a.a.) Human Recombinant Protein |
PROTO75771-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: RAD51D (1-328) Human Recombinant produced in E. coli is. a single polypeptide chain containing 351 amino acids and having a molecular mass of 37.4kDa. RAD51D (1-328) is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
XMIR-1 RNA oligo miRNA-1-3p with Xmotif |
XMIR-1 |
SBI |
10 rxn |
EUR 438 |
|
AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif |
AXMIR-1 |
SBI |
10 reactions |
EUR 438 |
|
Human KRAB-associated Protein 1 (KAP-1) AssayMax ELISA Kit |
EK2802-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit |
EI2200-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit |
EI2301-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit |
EMI2200-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Human Plasminogen Activator Inhibitor-1 (PAI-1) AssayMax ELISA Kit |
EP1100-1 |
AssayPro |
96 Well Plate |
EUR 417 |
Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 |
M04431-1 |
BosterBio |
100uL |
EUR 385 |
Description: Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 tested in WB, IHC, reactive to Human |
GAD1 iso1 Glutamate Decarboxylase 1 Isoform-1 Human Recombinant Protein |
PROTQ99259-1 |
BosterBio |
Regular: 20ug |
EUR 317 |
Description: GAD1 iso1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 617 amino acids (1-594 a.a) and having a molecular mass of 69.3kDa. GAD1 iso1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Envelope-1, Dengue Virus Subtype 1 Recombinant Protein, Insect Cells |
PROTB1PNJ5-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Recombinant Dengue Virus Subtype 1 produced in Insect Cells is a polypeptide chain containing amino acids 281-675 and having a molecular weight of approximately 50kDa. ;Dengue Envelope-1 is purified by proprietary chromatographic technique. |
TGF-b-1 Transforming Growth Factor-beta 1 Human protein |
PROTP01137-1 |
BosterBio |
Regular: 2.5ug |
EUR 1157 |
Description: Human Transforming Growth Factor-beta 1 purified from Human Platelets having a molecular mass of 25kDa.;The TGF-b 1 is purified by proprietary chromatographic techniques. |
MCP-1 Monocyte Chemotactic Protein-1 Mouse Recombinant Protein (CCL2) |
PROTP10148-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Monocyte Chemotactic Protein-1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa. ;The MCP-1 is purified by proprietary chromatographic techniques. |
MCP-1 Monocyte Chemotactic Protein-1 Human Recombinant Protein (CCL2) |
PROTP13500-1 |
BosterBio |
Regular: 20ug |
EUR 317 |
Description: Monocyte Chemotactic Protein-1 Human Recombinant also known as Monocyte Chemotactic and Activating Factor (MCAF) produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8.6kDa. ;The MCP-1 is purified by proprietary chromatographic techniques. |
StemRegenin 1, Free base |
2642-1 |
Biovision |
|
EUR 131 |
Anti-Periphilin 1 Antibody |
A06996-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse. |
Anti-Lyl-1 Antibody |
A07491-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat. |
Anti-GLI-1 Antibody |
A07972-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-Cerebellin 1 Antibody |
A09176-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-DOC-1 Antibody |
A09467-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse. |
Beta-Amyloid (1-11) |
A1002-1 |
ApexBio |
1 mg |
EUR 102 |
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. |
Amyloid ?-Protein (1-15) |
A1003-1 |
ApexBio |
1 mg |
EUR 113 |
Description: Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. |
ANP (1-11), rat |
A1009-1 |
ApexBio |
1 mg |
EUR 84 |
Description: Atrial Natriuretic Peptide (ANP) (C49H84N20O15S) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide that is synthesized, stored, and released by atrial myocytes in response to atrial distension, endothelin, and sympathetic stimulation. |
alpha-1 antitrypsin fragment |
A1051-1 |
ApexBio |
1 mg |
EUR 108 |
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily. |
BNP (1-32), human |
A1105-1 |
ApexBio |
1 mg |
EUR 177 |
Description: Basic natriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP) or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). |
Anti-NPDC-1 Antibody |
A12846-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-CNG-1 Antibody |
A05494-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat. |
B-Raf IN 1 |
B4727-1 |
ApexBio |
1 mg |
EUR 118 |
Nociceptin (1-13)NH2 |
B5102-1 |
ApexBio |
1 mg |
EUR 184 |
JIP-1 (153-163) |
B5130-1 |
ApexBio |
1 mg |
EUR 399 |
Nogo-66 (1-40) |
B5247-1 |
ApexBio |
1 mg |
EUR 609 |
Orphanin FQ (1-11) |
B5497-1 |
ApexBio |
1 mg |
EUR 226 |
Anti-Flk-1 Antibody |
A00901-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse. |
Anti-EDG-1 Antibody |
A01502-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat. |
Anti-ROBO-1 Antibody |
A01530-1 |
BosterBio |
100ug |
EUR 455 |
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
Anti-Bag-1 Antibody |
A02423-1 |
BosterBio |
50 ul |
EUR 397 |
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat. |
Anti-TUB 1 Antibody |
A02917-1 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Dok-1 Antibody |
A03039-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat. |
Anti-TFIIIB90-1 Antibody |
A03761-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse. |
Anti-Atrophin-1 Antibody |
A03828-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-PARP-1 Antibody |
A00122-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse. |
Anti-Presenilin 1 Antibody |
A00138-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat. |
Anti-PAI-1 Antibody |
A00637-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat. |
R-1 Methanandamide Phosphate |
C3352-1 |
ApexBio |
1 mg |
EUR 126 |
Description: R-1 Methanandamide Phosphate,a water soluble prodrug analog of AEA, exhibited similar activity to that of AEA in the growth inhibition of C6 glioma cells[1]. Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB). |
Ginkgolic Acid C15:1 |
C3421-1 |
ApexBio |
1 mg |
EUR 118 |
Description: Ginkgolic acid is an alkylphenol derivative that causes allergic skin inflammation. IC50 values of ginkgolic acid against the SUMOylation of RanGAP1-C2 are 3.0 ?M. Ginkgolic Acid, a Major Component of Ginkgo biloba Extract, inhibited SUMOylation in vitro and in vivo [1]. |
Individual Reaction Mix 1 |
G065-1 |
ABM |
200 reactions |
EUR 167 |
IGF-1, human recombinant |
P1016-.1 |
ApexBio |
100 µg |
EUR 763 |
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue |
Supercoiled pHOT-1 DNA |
TG2030-1 |
TopoGen |
25 ug |
EUR 246 |
Relaxed pHOT-1 DNA |
TG2035-1 |
TopoGen |
25 ug |
EUR 246 |
Human Heat Shock Factor Protein 1 (HSF 1) AssayMax ELISA kit |
EH5215-1 |
AssayPro |
96 Well Plate |
EUR 417 |
Human Insulin-like Growth Factor 1 (IGF-1) AssayMax ELISA Kit |
EI1001-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Mouse Insulin-like Growth Factor 1 (IGF-1) AssayMax ELISA Kit |
EMI1001-1 |
AssayPro |
96 Well Plate |
EUR 477 |
VAMP2 (1-94) Synaptobrevin-2 (1-94 a.a) Human Recombinant Protein |
PROTP63027-1 |
BosterBio |
Regular: 5ug |
EUR 317 |
Description: VAMP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-94 a.a) and having a molecular mass of 12.8kDa.;VAMP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
IL1RL1 Human, Interleukin-1 Receptor Like-1 Human Recombinant Protein, Sf9 |
PROTQ01638-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: IL 1RL1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (19-328 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 318 amino acids and having a molecular mass of 36.0kDa.;IL 1RL1 shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques. |
DCTN2 (1-406) Dynactin 2 (1-406 a.a.) Human Recombinant Protein |
PROTQ13561-1 |
BosterBio |
Regular: 20ug |
EUR 317 |
Description: Dynactin 2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 429 amino acids (1-406 a.a) and having a molecular mass of 47.2kDa.;DCTN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
STX1A (1-265) Syntaxin-1A (1-265 a.a) Human Recombinant Protein |
PROTQ16623-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: STX1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-265 a.a) and having a molecular mass of 30.7kDa.  |
GLP-1 Glucagon Like Peptide-1 (31 a.a.) Human Recombinant Protein |
PROTP01275-1 |
BosterBio |
Regular: 50ug |
EUR 317 |
Description: Glucagon Like Peptide-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 31 amino acids and having a molecular mass of 3298.7 Dalton. The GLP-1 is purified by proprietary chromatographic techniques. |
Importantly, TC patients with locally advanced disease (defined as>>pT1aN0) and high CD44/nOTP expression (N = 26; 38 %) had excellent RFS (p = 0.005) compared to those with the same stage but low CD44 and/or nOTP (N = 11; 16 %). Additionally, the combination of CD44/nOTP expression and tumour growth pattern led to a more accurate prognostic system compared to the established WHO classification of PC tumours (concordance index = 0.902 vs 0.811, respectively, p < 0.001). Assessment of CD44/nOTP expression combined with tumour growth pattern identifies clear groups with largely different prognosis. These findings provide important information on how patients with these resected cancers should be followed up.